Tamgo Plus
Comprehensive dual-action combination therapy uniting an alpha-1A selective blocker with a 5-alpha reductase inhibitor for superior management of moderate-to-severe BPH symptoms and prostate volume reduction.
What is Tamgo Plus?
Tamgo Plus is a fixed-dose combination pharmaceutical product by Inspiron Scientific Pvt. Ltd. containing Tamsulosin Hydrochloride 0.4mg and Dutasteride 0.5mg in a single tablet. This powerful dual-action formulation combines an alpha-1A adrenoceptor antagonist with a dual 5-alpha reductase inhibitor to provide comprehensive management of moderate-to-severe Benign Prostatic Hyperplasia (BPH).
Tamsulosin HCl rapidly relaxes the smooth muscle of the prostate and bladder neck to provide quick symptomatic relief, while Dutasteride inhibits both Type I and Type II 5-alpha reductase enzymes, blocking the conversion of testosterone to dihydrotestosterone (DHT) — the primary hormone responsible for prostate enlargement. Together, they address both the dynamic and static components of BPH, offering faster symptom relief and long-term prostate volume reduction in a single convenient tablet.
Detailed Product Information
Everything healthcare professionals and patients need to know about Tamgo Plus — from dual composition and mechanism of action to clinical benefits and administration guidelines.
• Tamsulosin Hydrochloride 0.4mg
• Dutasteride 0.5mg
Dosage Form: Combination Tablets
Type: Fixed-Dose Combination (FDC)
Route: Oral Administration
Category: Alpha-1A Blocker + Dual 5-ARI
Marketed by: Inspiron Scientific Pvt. Ltd.
Dutasteride (Dual 5-ARI): Inhibits both Type I and Type II 5-alpha reductase enzymes, blocking the conversion of testosterone to DHT by over 90%. This leads to progressive shrinkage of the enlarged prostate, reducing the static component of obstruction and lowering the risk of acute urinary retention (AUR) and BPH-related surgery.
Together, they provide rapid symptom relief + long-term disease modification.
- Moderate-to-severe BPH symptoms requiring combination therapy
- Patients at risk of disease progression
- Enlarged prostate (prostate volume ≥30 mL)
- Reduction of risk of acute urinary retention (AUR)
- Reduction of risk of BPH-related surgery
- Rapid relief of obstructive & irritative urinary symptoms
- Long-term prostate volume reduction
- Rapid symptom relief from Tamsulosin — improvement within 1–2 weeks
- Significant prostate volume reduction from Dutasteride — up to 25% shrinkage over 6–12 months
- Reduces risk of AUR by 68% and BPH-related surgery by 71% vs. placebo (CombAT study)
- Superior IPSS improvement compared to either monotherapy alone
- Dual 5-ARI action — >90% suppression of serum DHT
- Single-tablet convenience — improved patient compliance over taking two separate medications
- Proven long-term efficacy — sustained benefits demonstrated over 4 years in landmark clinical trials
Administration: Take approximately 30 minutes after the same meal each day. Swallow whole with a glass of water — do not crush, chew, or break the tablet.
Dose Titration: No dose titration required. Initiate directly with the fixed-dose combination.
Missed Dose: If a dose is missed, skip it and take the next dose at the usual time. Do not double the dose.
Duration: As directed by the physician. Combination therapy is typically prescribed for long-term use. Clinical benefits of Dutasteride become most evident after 3–6 months of continuous treatment.
Note: Dutasteride capsule contents may cause irritation to the oral mucosa if the tablet is damaged. Handle with care.
Packaging: Available in alu-alu blister pack for optimal product protection and stability.
Shelf Life: As mentioned on the pack. Do not use after the expiry date.
Disposal: Do not dispose of unused tablets in household waste or wastewater. Consult your pharmacist for proper disposal methods.
Special Handling: Women who are pregnant or may become pregnant should not handle damaged or broken tablets due to the risk of Dutasteride absorption through the skin.
Understanding BPH & Why Combination Therapy Matters
Benign Prostatic Hyperplasia (BPH) is a progressive, non-cancerous enlargement of the prostate gland that becomes increasingly common as men age. It has two key components that cause urinary symptoms: the dynamic component (increased smooth muscle tone) and the static component (physical enlargement of the prostate gland).
While alpha blockers like Tamsulosin address the dynamic component for rapid relief, they don’t reduce prostate size. Tamgo Plus combines Tamsulosin with Dutasteride — a dual 5-alpha reductase inhibitor that shrinks the prostate over time. This dual-action approach delivers fast symptom relief today and prevents disease progression tomorrow, reducing the risk of complications like acute urinary retention and the need for surgery.
Common Symptoms of BPH
Recognizing the signs early can lead to timely combination therapy and better long-term outcomes. Consult your doctor if you experience any of the following:
How Tamgo Plus Works
Tamgo Plus delivers a two-pronged attack on BPH through complementary mechanisms — providing immediate symptom relief and long-term prostate shrinkage in one convenient tablet.
- Take Tamgo Plus only as prescribed by your doctor
- Take approximately 30 minutes after the same meal each day
- Do not crush, chew, or break the tablet — swallow whole
- May cause dizziness or lightheadedness — rise slowly from sitting or lying position
- Dutasteride may lower PSA levels by approximately 50% — inform your doctor if being screened for prostate cancer
- Women who are pregnant or may become pregnant must NOT handle damaged or broken tablets (Dutasteride can be absorbed through skin and may harm a male fetus)
- Men taking Dutasteride should not donate blood until at least 6 months after stopping treatment
- Inform your ophthalmologist about Tamsulosin use before any planned eye surgery (risk of IFIS)
- Not intended for use in women or children
- If symptoms worsen or do not improve after several weeks of treatment
- If you experience blood in urine, painful urination, or inability to urinate (acute retention)
- If you notice breast tenderness, enlargement, or unusual lumps
- If you have a history of low blood pressure (orthostatic hypotension)
- If you have severe liver impairment (Dutasteride is extensively metabolized by the liver)
- Before any planned surgery, especially eye surgery (cataract or glaucoma)
- If you experience prolonged dizziness, fainting, or palpitations
- If you are taking other medications for blood pressure, prostate conditions, or CYP3A4 inhibitors
- If you experience sexual side effects such as decreased libido, erectile dysfunction, or ejaculation disorders
- If you have a known allergy to Tamsulosin, Dutasteride, or other 5-alpha reductase inhibitors
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