Silgo D8
Dual-action combination therapy uniting an alpha-1A selective blocker with a potent 5-alpha reductase inhibitor for comprehensive management of Benign Prostatic Hyperplasia (BPH).
What is Silgo D8?
Silgo D8 is a fixed-dose combination pharmaceutical product by Inspiron Scientific Pvt. Ltd. containing Silodosin 8mg and Dutasteride 0.5mg in capsule form. It combines two complementary mechanisms — an alpha-1A selective adrenoceptor antagonist and a dual 5-alpha reductase inhibitor — for the comprehensive treatment of Benign Prostatic Hyperplasia (BPH).
This synergistic combination addresses both the dynamic component (smooth muscle tone mediated by alpha receptors) and the static component (enlarged prostate tissue driven by DHT) of BPH, providing rapid symptom relief along with long-term prostate size reduction.
Detailed Product Information
Everything healthcare professionals and patients need to know about Silgo D8 — from dual composition to comprehensive clinical benefits.
• Silodosin 8mg
• Dutasteride 0.5mg
Dosage Form: Hard Gelatin Capsules
Route: Oral Administration
Category: Alpha Blocker + 5-ARI Combination
Marketed by: Inspiron Scientific Pvt. Ltd.
Dutasteride (5-ARI): Inhibits both Type 1 and Type 2 isoforms of 5-alpha reductase, blocking the conversion of testosterone to dihydrotestosterone (DHT), thereby reducing prostate volume over time.
- Difficulty in initiating urination
- Weak or interrupted urine stream
- Frequent or urgent urination
- Nocturia (nighttime urination)
- Risk reduction of acute urinary retention
- Reducing the need for BPH-related surgery
- Rapid symptom relief — Silodosin provides noticeable improvement within days
- Long-term prostate shrinkage — Dutasteride reduces prostate volume by up to 25% over 6–12 months
- Significant improvement in IPSS scores (International Prostate Symptom Score)
- Improved peak urinary flow rate (Qmax)
- Reduced risk of acute urinary retention & BPH-related surgery
- High alpha-1A selectivity — minimal impact on blood pressure
Administration: Take with a meal, preferably at the same time each day. Swallow whole — do not crush, chew, or open the capsule. The capsule contents may irritate the oral mucosa if opened.
Missed Dose: If a dose is missed, skip it and take the next dose at the usual time. Do not double the dose.
Duration: As directed by the physician. Long-term use is typically required for sustained benefits from Dutasteride.
Packaging: Available in alu-alu blister pack for optimal product protection.
Shelf Life: As mentioned on the pack. Do not use after the expiry date.
Special Note: Leaking capsules should not be used. Women who are or may become pregnant should not handle damaged capsules.
Understanding Benign Prostatic Hyperplasia
Benign Prostatic Hyperplasia (BPH) is a common, non-cancerous enlargement of the prostate gland that affects men as they age. The prostate surrounds the urethra, and when it enlarges, it can squeeze or partially block the urethra, leading to bothersome urinary problems that worsen over time if untreated.
BPH is not prostate cancer and does not increase the risk of cancer. However, it can significantly impact quality of life. BPH involves two components: the dynamic component (increased smooth muscle tone) and the static component (physical enlargement of the prostate). Silgo D8 is designed to address both.
Common Symptoms of BPH
Recognizing the signs early can lead to timely treatment and better outcomes. Consult your doctor if you experience any of the following:
How Silgo D8 Helps
Silgo D8 works through two complementary mechanisms to deliver both rapid symptom relief and long-term prostate management.
- Take Silgo D8 only as prescribed by your doctor
- Always take with food (preferably after a meal) for optimal absorption
- Do not crush, chew, or open the capsule — swallow whole
- Women who are pregnant or may become pregnant should not handle broken or leaking capsules (Dutasteride is absorbed through skin)
- Inform your doctor about all current medications, including herbal supplements
- May cause dizziness — exercise caution while driving or operating machinery
- May affect PSA (Prostate Specific Antigen) levels — inform your doctor before PSA testing
- Not intended for use in women or children
- If symptoms worsen or do not improve after treatment
- If you experience blood in urine or painful urination
- If you have a history of low blood pressure or liver/kidney problems
- Before any planned eye surgery (Intraoperative Floppy Iris Syndrome may occur)
- If you experience prolonged dizziness or fainting spells
- If you notice breast changes such as lumps, pain, or enlargement
- If you are taking other medications for blood pressure or prostate conditions
- Do not donate blood until at least 6 months after stopping Silgo D8
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